Citric Acid

Citric Acid

SCHEMBL8647461

Cc1cccc(S(=O)(=O)O)c1C.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.43
KDM4E B2RXH2 4/20 0.40
LMNA P02545 3/20 0.40
SLC13A5 Q86YT5 8/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 1/20 0.39
KMT2A Q03164 1/20 0.39
POLB P06746 1/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
MYC P01106 1/20 0.36
MAPT P10636 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL28587369 0.85 ALDH1A1 (0.56) ALDH1A1KDM4ELMNASLC13A5CYP1A2
SCHEMBL31506947 0.79 MYC (0.46) ALDH1A1CYP1A2MEN1KMT2AMYC
SCHEMBL3780 0.79 MYC (0.46) ALDH1A1CYP1A2MEN1KMT2AMYC
SCHEMBL4400073 0.79 MYC (0.46) ALDH1A1CYP1A2MEN1KMT2AMYC
Acetic Acid SCHEMBL28677429 0.78 CASP1 (0.40) ALDH1A1KDM4ELMNACYP1A2MEN1
Citric Acid SCHEMBL27897976 0.78 ALDH1A1 (0.60) ALDH1A1KDM4ELMNASLC13A5CYP1A2
Propane SCHEMBL27725291 0.78 MYC (0.42) ALDH1A1LMNACYP1A2MEN1KMT2A
SCHEMBL360362 0.78 MYC (0.44) ALDH1A1CYP1A2MEN1KMT2AMYC
Hydrochloric Acid SCHEMBL3138998 0.78 MYC (0.44) ALDH1A1CYP1A2MEN1KMT2AMYC
Ammonia Solution, Strong SCHEMBL59677 0.78 MYC (0.44) ALDH1A1CYP1A2MEN1KMT2AMYC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861064-A1 HAIR STYLING COMPOSITIONS CONTAINING NON-SILICONE AND SILICONE GRAFTED POLYMERS AND LOW LEVEL OF A VOLATILE HYDROCARBON SOLVENT THE PROCTER & GAMBLE COMPANY (US) 1998-09-02 EP disclosed
WO-1997015275-A1 HAIR STYLING COMPOSITIONS CONTAINING NON-SILICONE AND SILICONE GRAFTED POLYMERS AND LOW LEVEL OF A VOLATILE HYDROCARBON SOLVENT THE PROCTER & GAMBLE COMPANY (US) 1997-05-01 WO disclosed