Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 12/20 | 0.76 |
| ▸ | SLC1A3 | P43003 | 11/20 | 0.76 |
| ▸ | SLC1A1 | P43005 | 11/20 | 0.76 |
| ▸ | MMP2 | P08253 | 3/20 | 0.65 |
| ▸ | MMP3 | P08254 | 3/20 | 0.65 |
| ▸ | MMP13 | P45452 | 3/20 | 0.65 |
| ▸ | MMP9 | P14780 | 3/20 | 0.65 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.65 |
| ▸ | MMP1 | P03956 | 2/20 | 0.65 |
| ▸ | MMP7 | P09237 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973093 | 0.88 | MMP2 (0.82) | SLC1A2SLC1A3SLC1A1MMP2MMP3 | |
| SCHEMBL6561375 | 0.88 | MMP2 (0.82) | SLC1A2SLC1A3SLC1A1MMP2MMP3 | |
| SCHEMBL21451101 | 0.88 | MMP2 (0.82) | SLC1A2SLC1A3SLC1A1MMP2MMP3 | |
| SCHEMBL11588570 | 0.86 | SLC1A2 (1.00) | SLC1A2SLC1A3SLC1A1 | |
| SCHEMBL15251716 | 0.82 | SLC1A3 (0.60) | SLC1A2SLC1A3SLC1A1MMP2MMP3 | |
| SCHEMBL15251715 | 0.82 | SLC1A3 (0.60) | SLC1A2SLC1A3SLC1A1MMP2MMP3 | |
| SCHEMBL8458546 | 0.81 | SLC1A2 (0.77) | SLC1A2SLC1A3SLC1A1ADAMTS4 | |
| SCHEMBL7872813 | 0.80 | SMN1; SMN2 (0.54) | SLC1A2SLC1A3SLC1A1MMP2MMP3 | |
| SCHEMBL702794 | 0.80 | ADAMTS4 (0.81) | SLC1A2SLC1A3SLC1A1MMP2MMP3 | |
| SCHEMBL790069 | 0.80 | ADAMTS4 (0.81) | SLC1A2SLC1A3SLC1A1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710159-A | IMIDAZOLIN-2-YLAMINOPROPOXY)ISOXAZOL-5-CARBONYLAMINO-2 -BENZYLOXYCARBONYLAMINOPROPIONIC ACID AS ANTIINFLAMMATORY AGENTS, BONE DEGRADATION, TUMORS, METASTASES AND THROMBOSIS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-01-20 | — | — | US | disclosed |