Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314113 | 0.88 | KMT2A (0.45) | EDNRAKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL6315909 | 0.80 | EDNRA (0.57) | EDNRA | |
| SCHEMBL795156 | 0.79 | KMT2A (0.38) | EDNRAKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL6313692 | 0.78 | EDNRB (0.48) | EDNRA | |
| SCHEMBL22404286 | 0.71 | EDNRA (0.56) | EDNRAKMT2AALDH1A1MEN1TAS1R3 | |
| SCHEMBL805660 | 0.70 | EDNRA (0.55) | EDNRAKMT2AALDH1A1MEN1TAS1R3 | |
| SCHEMBL1746047 | 0.70 | PTGS2 (0.56) | EDNRAKMT2AALDH1A1MEN1TAS1R3 | |
| SCHEMBL803787 | 0.70 | EDNRA (0.56) | EDNRAKMT2AMEN1TAS1R3TAS1R1 | |
| SCHEMBL4996294 | 0.69 | EDNRA (0.54) | EDNRAKMT2AALDH1A1MEN1TAS1R3 | |
| SCHEMBL805662 | 0.69 | EDNRA (0.54) | EDNRAKMT2AALDH1A1MEN1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821256-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-10-13 | — | — | US | disclosed |