Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | EDNRA | P25101 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.52 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22404286 | 0.86 | EDNRA (0.56) | EDNRAKMT2AHPGDTAS1R3TAS1R1 | |
| SCHEMBL12053329 | 0.85 | CYP3A4 (0.55) | PTGS2PTGS1KMT2AHPGDMEN1 | |
| SCHEMBL805660 | 0.84 | EDNRA (0.55) | EDNRAKMT2AHPGDTAS1R3TAS1R1 | |
| SCHEMBL27598809 | 0.83 | PTGS1 (0.63) | PTGS2PTGS1KMT2AHPGDMEN1 | |
| SCHEMBL4996294 | 0.83 | EDNRA (0.54) | EDNRAKMT2AHPGDTAS1R3TAS1R1 | |
| SCHEMBL14032401 | 0.83 | EDNRA (0.54) | EDNRAKMT2AHPGDTAS1R3TAS1R1 | |
| SCHEMBL805662 | 0.83 | EDNRA (0.54) | EDNRAKMT2AHPGDTAS1R3TAS1R1 | |
| SCHEMBL10204938 | 0.83 | EDNRA (0.54) | EDNRAKMT2AHPGDTAS1R3TAS1R1 | |
| SCHEMBL18252774 | 0.82 | PTGS1 (0.61) | PTGS2PTGS1KMT2AHPGDMEN1 | |
| SCHEMBL15695562 | 0.82 | PTGS1 (0.66) | PTGS2PTGS1KMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385934-B1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | COUNCIL SCIENT IND RES (IN) | 2016-05-18 | — | — | EP | disclosed |
| EP-2385934-B1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | COUNCIL SCIENT IND RES (IN) | 2016-05-18 | — | — | EP | disclosed |
| US-9302967-B2 | Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-04-05 | — | — | US | disclosed |
| US-9302967-B2 | Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-04-05 | — | — | US | disclosed |
| US-9302967-B2 | Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-04-05 | — | — | US | disclosed |
| US-9290473-B2 | Inhibitors of phosphatidylinositol-3-kinase (PI3) and inducers of nitric oxide (NO) | COUCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-03-22 | — | — | US | disclosed |
| US-9290473-B2 | Inhibitors of phosphatidylinositol-3-kinase (PI3) and inducers of nitric oxide (NO) | COUCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-03-22 | — | — | US | disclosed |
| US-9290473-B2 | Inhibitors of phosphatidylinositol-3-kinase (PI3) and inducers of nitric oxide (NO) | COUCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-03-22 | — | — | US | disclosed |
| US-20140135393-A1 | SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-05-15 | — | — | US | disclosed |
| US-20140135393-A1 | SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-05-15 | — | — | US | disclosed |
| US-20120190738-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-07-26 | — | — | US | disclosed |
| EP-2385934-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | Council of Scientific & Industrial Research (IN) | 2011-11-16 | — | — | EP | disclosed |
| US-8041964-B2 | Ultra low power wake-up circuit | COVIDIEN AG (CH) | 2011-10-18 | — | — | US | disclosed |
| WO-2010079423-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-07-15 | — | — | WO | disclosed |
| WO-2010079423-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-07-15 | — | — | WO | disclosed |
| EP-1021418-B1 | SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF | EURO CELTIQUE SA (LU) | 2004-05-19 | — | — | EP | disclosed |
| EP-1021418-A4 | SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF | COCENSYS INC (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1021418-A1 | SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF | Cocensys, Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5891871-A | 2-AMINO-3-(3-HYDROXY-5-METHYLISOXAZ-4-YL)PROPIONIC ACID RECEPTOR ANTAGONISTS; TREATING NEURONAL LOSS ASSOCIATED WITH STROKE, ISCHEMIA, CNS TRAUMA, HYPOGLYCEMIA OR SURGERY; OR TREATING NEURODEGENERATIVE DISEASES. | COCENSYS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997034878-A1 | SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF | COCENSYS, INC. (US) | 1997-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135393-A1 | SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA | IL5, IL4, IL33 | PTGS2 155/4885PTGS1 61/4885EDNRA 742/4885 |
| US-20120190738-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE (PI3) AND INDUCERS OF NITRIC OXIDE (NO) | NOS2, NOS3, NOS1 | PTGS2 39/4885PTGS1 27/4885EDNRA 1122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.