Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 5/20 | 0.53 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.46 |
| ▸ | PDGFRB known ✓ | P09619 | 12/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | KIF5B | P33176 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647215 | 0.90 | EGFR (0.56) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL9115373 | 0.89 | EGFR (0.56) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8649611 | 0.88 | EGFR (0.52) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8649464 | 0.87 | EGFR (0.53) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8647393 | 0.87 | EGFR (0.56) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8652543 | 0.86 | EGFR (0.54) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL9115998 | 0.85 | EGFR (0.54) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8647397 | 0.84 | EGFR (0.57) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8649679 | 0.84 | EGFR (0.56) | EGFRCSF1RKDRPDGFRB | |
| SCHEMBL8652546 | 0.84 | EGFR (0.56) | EGFRCSF1RRETKIF5BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736534-A | HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA | PFIZER INC. (US) | 1998-04-07 | — | — | US | disclosed |