Desonide

SCHEMBL8649633

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Desonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	7/20	0.69

▸	PGR	P06401	6/20	0.69

▸	CYP3A4	P08684	9/20	0.60

▸	AR	P10275	3/20	0.60

▸	USP2	O75604	1/20	0.60

▸	LMNA	P02545	4/20	0.59

▸	HIF1A	Q16665	4/20	0.59

▸	NR1I2	O75469	1/20	0.59

▸	HSD17B10	Q99714	4/20	0.59

▸	ABCB11	O95342	3/20	0.59

▸	CYP2C19	P33261	2/20	0.59

▸	NR3C2	P08235	2/20	0.59

▸	TNF	P01375	1/20	0.59

▸	IL6	P05231	1/20	0.59

▸	SERPINA6	P08185	1/20	0.59

▸	GLUL	P15104	1/20	0.59

▸	ADAM17	P78536	1/20	0.59

▸	GPBAR1	Q8TDU6	1/20	0.59

▸	KDM4E	B2RXH2	1/20	0.54

▸	HTR1A	P08908	1/20	0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Rofleponide SCHEMBL2853947	0.89	CYP3A4 (0.59)	NR3C1PGRCYP3A4ARUSP2
Desonide SCHEMBL17503255	0.88	NR3C1 (0.76)	NR3C1PGRCYP3A4ARLMNA
Halcinonide SCHEMBL8453347	0.85	NR3C1 (0.72)	NR3C1PGRCYP3A4ARUSP2
Halcinonide SCHEMBL28149502	0.84	NR3C1 (0.71)	NR3C1PGRCYP3A4ARUSP2
Fludrocortisone Acetate SCHEMBL5967523	0.84	HIF1A (0.72)	NR3C1PGRCYP3A4ARLMNA
Desonide SCHEMBL12235707	0.83	NR3C1 (1.00)	NR3C1PGRCYP3A4ARLMNA
Desonide SCHEMBL9848320	0.83	NR3C1 (1.00)	NR3C1PGRCYP3A4ARLMNA
Desonide SCHEMBL21570018	0.83	NR3C1 (1.00)	NR3C1PGRCYP3A4ARLMNA
Desonide SCHEMBL4295093	0.83	NR3C1 (1.00)	NR3C1PGRCYP3A4ARLMNA
Desonide SCHEMBL1649865	0.83	NR3C1 (1.00)	NR3C1PGRCYP3A4ARLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5837289-A	ORGANOGEL COMPRISING FATTY ACID PHOSPHOLIPID EMULSIFYING AGENT AND FATTY ACID OR ESTER THEREOF	IMPRIMIS PHARMACEUTICALS, INC.	1998-11-17	—	—	US	disclosed