Sugi Predict

Sugi Predict / Compounds / Desonide

Desonide

Desonide

SCHEMBL17503255

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Desonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 8/20 0.76
▸ PGR P06401 6/20 0.76
▸ HIF1A Q16665 8/20 0.67
▸ CYP3A4 P08684 8/20 0.67
▸ HSD17B10 Q99714 6/20 0.67
▸ CYP2C19 P33261 4/20 0.67
▸ ABCB11 O95342 4/20 0.67
▸ NR3C2 P08235 3/20 0.67
▸ AR P10275 3/20 0.67
▸ SERPINA6 P08185 2/20 0.67
▸ TNF P01375 1/20 0.67
▸ IL6 P05231 1/20 0.67
▸ GLUL P15104 1/20 0.67
▸ ADAM17 P78536 1/20 0.67
▸ GPBAR1 Q8TDU6 1/20 0.67
▸ SMN1; SMN2 Q16637 3/20 0.66
▸ NFKB1 P19838 2/20 0.66
▸ SHBG P04278 1/20 0.66
▸ MAPT P10636 1/20 0.66
▸ KMT2A Q03164 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Prednisolone SCHEMBL3884401 0.89 HIF1A (0.85) NR3C1PGRHIF1ACYP3A4HSD17B10
Dexbudesonide SCHEMBL8159866 0.88 NR3C1 (0.78) NR3C1PGRHIF1ACYP3A4HSD17B10
Desonide SCHEMBL8649633 0.88 NR3C1 (0.69) NR3C1PGRHIF1ACYP3A4HSD17B10
Desonide SCHEMBL9848320 0.87 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
SCHEMBL2020622 0.87 HIF1A (0.73) NR3C1PGRHIF1ACYP3A4HSD17B10
Desonide SCHEMBL21570018 0.87 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Desonide SCHEMBL1650014 0.87 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Desonide SCHEMBL1649865 0.87 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Desonide SCHEMBL12235707 0.87 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10
Desonide SCHEMBL4295093 0.87 NR3C1 (1.00) NR3C1PGRHIF1ACYP3A4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170312220-A1 SPRAY FOAM PRODUCT DELCOR ASSET CORP (US) 2017-11-02 — — US disclosed
US-9737481-B2 Spray foam corticosteroid product Delcor Assett Corporation (US) 2017-08-22 — — US disclosed
US-20160220488-A1 SPRAY FOAM CORTICOSTEROID PRODUCT DELCOR ASSET CORPORATION 2016-08-04 — — US disclosed
US-9345666-B1 Spray foam corticosteroid product DELCOR ASSET CORPORATION (US) 2016-05-24 — — US disclosed
US-9265727-B1 Spray foam corticosteroid product DELCOR ASSET CORPORATION (US) 2016-02-23 — — US disclosed
Send feedback