Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18371949 | 0.89 | MAPT (0.46) | MAPTTSHRCYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL8649477 | 0.86 | L3MBTL1 (0.49) | MAPTTSHRCYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL27583161 | 0.86 | MAPT (0.47) | MAPTTSHRCYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL3610075 | 0.85 | MAPT (0.49) | MAPTTSHRCYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL1572954 | 0.83 | L3MBTL1 (0.56) | MAPTTSHRL3MBTL1ALDH1A1CRHBP | |
| SCHEMBL30619954 | 0.83 | L3MBTL1 (0.56) | MAPTTSHRL3MBTL1ALDH1A1CRHBP | |
| SCHEMBL18371980 | 0.83 | MAPT (0.44) | MAPTTSHRCYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL2814202 | 0.82 | MAPT (0.43) | MAPTTSHRCYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL3612159 | 0.81 | MAPT (0.45) | MAPTTSHRCYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL406358 | 0.80 | MAPT (0.51) | MAPTTSHRCYP3A4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719152-A | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0627434-A1 | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-12-07 | — | — | EP | disclosed |