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SCHEMBL8650323

SCHEMBL8650323

CCCCC1(c2cc(F)c(C3CC=C(F)CC3)c(F)c2)CCCCC1

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 13/20 0.36
▸ CNR1 P21554 5/20 0.35
▸ SLC6A2 P23975 1/20 0.32
▸ SLC6A4 P31645 1/20 0.32
▸ SLC6A3 Q01959 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9013335 0.70 CNR2 (0.44) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL9013458 0.67 CNR2 (0.43) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL8646349 0.67 CYP2C9 (0.37) —
SCHEMBL9013345 0.66 CNR2 (0.45) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL9247089 0.66 CNR2 (0.45) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL9013677 0.66 CNR2 (0.45) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL9013370 0.66 CNR2 (0.45) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL9013555 0.66 CNR2 (0.38) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL9013341 0.65 SLC6A3 (0.58) CNR2CNR1SLC6A2SLC6A4SLC6A3
SCHEMBL12002389 0.65 SLC6A3 (0.59) CNR2CNR1SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5800734-A 1-fluorocyclohexene-difluorophenyl derivatives ROLIC AG (CH) 1998-09-01 — — US disclosed
EP-0736513-A1 1-Fluorcyclohexene-difluorphenyl derivatives F. HOFFMANN-LA ROCHE AG (CH) 1996-10-09 — — EP disclosed