Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8651806 | 0.94 | NR1H4 (0.54) | NR1H4LTB4RLTB4R2ALDH1A1SGMS2 | |
| SCHEMBL8653472 | 0.93 | NR1H4 (0.53) | NR1H4HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8654007 | 0.91 | NR1H4 (0.52) | NR1H4LTB4RLTB4R2ALDH1A1SGMS2 | |
| SCHEMBL8655412 | 0.90 | NR1H4 (0.51) | NR1H4KDM4ELTB4RLTB4R2SGMS2 | |
| SCHEMBL8651831 | 0.88 | NR1H4 (0.53) | NR1H4LTB4RLTB4R2 | |
| SCHEMBL8560737 | 0.88 | NR1H4 (0.53) | NR1H4LMNALTB4RLTB4R2SGMS2 | |
| SCHEMBL8650467 | 0.88 | NR1H4 (0.52) | NR1H4HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL8568257 | 0.88 | NR1H4 (0.52) | NR1H4LTB4RLTB4R2 | |
| SCHEMBL8653660 | 0.87 | NR1H4 (0.49) | NR1H4KDM4ELMNALTB4RLTB4R2 | |
| SCHEMBL6759095 | 0.87 | NR1H4 (0.52) | NR1H4LMNALTB4RLTB4R2SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579412-B1 | 1,2,4-trioxygenated benzene derivatives useful as a leukotriene antagonists | LILLY CO ELI (US) | 1998-10-07 | — | — | EP | disclosed |
| US-5352690-A | For asthma, allergies | ELI LILLY AND COMPANY (US) | 1994-10-04 | — | — | US | disclosed |
| EP-0579412-A1 | 1,2,4-trioxygenated benzene derivatives useful as a leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1994-01-19 | — | — | EP | disclosed |