Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8651806 | 0.90 | NR1H4 (0.54) | NR1H4LTB4RLTB4R2SGMS2 | |
| SCHEMBL8650341 | 0.90 | NR1H4 (0.54) | NR1H4LTB4RLTB4R2SGMS2KDM4E | |
| SCHEMBL8653472 | 0.89 | NR1H4 (0.53) | NR1H4LTB4RLTB4R2KDM4E | |
| SCHEMBL8654007 | 0.87 | NR1H4 (0.52) | NR1H4LTB4RLTB4R2SGMS2 | |
| SCHEMBL8651831 | 0.85 | NR1H4 (0.53) | NR1H4LTB4RLTB4R2 | |
| SCHEMBL8560737 | 0.85 | NR1H4 (0.53) | NR1H4LTB4RLTB4R2SGMS2 | |
| SCHEMBL8650467 | 0.84 | NR1H4 (0.52) | NR1H4LTB4RLTB4R2SGMS2TDP1 | |
| SCHEMBL8568257 | 0.84 | NR1H4 (0.52) | NR1H4LTB4RLTB4R2 | |
| SCHEMBL8653660 | 0.84 | NR1H4 (0.49) | NR1H4LTB4RLTB4R2SGMS2KDM4E | |
| SCHEMBL6759095 | 0.84 | NR1H4 (0.52) | NR1H4LTB4RLTB4R2SGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579412-B1 | 1,2,4-trioxygenated benzene derivatives useful as a leukotriene antagonists | LILLY CO ELI (US) | 1998-10-07 | — | — | EP | disclosed |
| US-5352690-A | For asthma, allergies | ELI LILLY AND COMPANY (US) | 1994-10-04 | — | — | US | disclosed |
| EP-0579412-A1 | 1,2,4-trioxygenated benzene derivatives useful as a leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1994-01-19 | — | — | EP | disclosed |