SCHEMBL8650426

SCHEMBL8650426

N#CCC(=O)Nc1cccc(O)c1

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.61
HSD17B10 Q99714 1/20 0.61
CYP1A2 P05177 2/20 0.54
ALDH1A1 P00352 1/20 0.54
NLRP3 Q96P20 10/20 0.54
CYP2C19 P33261 1/20 0.54
MAPT P10636 1/20 0.52
RAB9A P51151 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
JAK2 O60674 1/20 0.52
JAK3 P52333 1/20 0.52
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
MAPK1 P28482 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8072208 0.82 CA12 (0.51) HTTHSD17B10CYP1A2ALDH1A1CYP2C19
SCHEMBL5142374 0.82 ALDH1A1 (0.66) CYP1A2ALDH1A1NLRP3MAPTRAB9A
SCHEMBL1260084 0.82 KMT2A (0.70) HTTHSD17B10CYP1A2ALDH1A1CYP2C19
SCHEMBL14517868 0.82 HSD17B10 (0.59) HTTHSD17B10CYP1A2ALDH1A1CYP2C19
SCHEMBL8623425 0.82 HSD17B10 (0.63) HTTHSD17B10CYP1A2ALDH1A1CYP2C19
SCHEMBL11421956 0.82 HTT (0.59) HTTHSD17B10CYP1A2ALDH1A1CYP2C19
SCHEMBL8996041 0.82 MAPT (0.59) HTTHSD17B10CYP1A2ALDH1A1CYP2C19
SCHEMBL2263103 0.81 JAK2 (0.63) HTTHSD17B10CYP1A2CYP2C19JAK2
SCHEMBL1260216 0.80 SMN1; SMN2 (0.62) HTTHSD17B10CYP1A2ALDH1A1CYP2C19
SCHEMBL11197480 0.80 HTT (0.64) HTTHSD17B10CYP1A2ALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4304831-A ELECTROGRAPHY; COPIES RICOH CO., LTD. (JP) 1981-12-08 US claimed
JP-57189130-A None JP disclosed
CN-1221853-C Diazo copying material, diazo copying method and diazo copied image forming device RICOH KK (JP) 2005-10-05 CN disclosed
CN-1330286-A Diazo copying material, diazo copying method and diazo copied image forming device RICOH KK (JP) 2002-01-09 CN disclosed
US-5849449-A Electrostatographic developer having toner particles containing polymers of (2-cyanoacetamido)phenyl acrylates polymers EASTMAN KODAK COMPANY (US) 1998-12-15 US disclosed
US-5691099-A DISCOLORATION INHIBITION; PRESERVATION; IMAGE QUALITY RICOH COMPANY, LTD. (JP) 1997-11-25 US disclosed
US-5556733-A COUPLER RICOH COMPANY, LTD. (JP) 1996-09-17 US disclosed
US-5478689-A With coupler contained in microcapsules made of alkali-soluble resin RICOH COMPANY, LTD. (JP) 1995-12-26 US disclosed
EP-0415885-B1 Bis-Phthalideactones, process for their preparation, and their use in recording materials CIBA GEIGY AG (CH) 1995-03-15 EP disclosed
US-5244860-A PRESSURE-SENSITIVE RECORDING AND TRANSFER MATERIAL CIBA-GEIGY CORPORATION (US) 1993-09-14 US disclosed
EP-0465403-A1 Pressure sensitive recording and transfer material CIBA-GEIGY AG (CH) 1992-01-08 EP disclosed
EP-0463987-A1 Pressure sensitive recording material CIBA-GEIGY AG (CH) 1992-01-02 EP disclosed
US-5024988-A Color reaction system comprising a polycyclic heterocyclic compound, a leuko dye to form a chromogen with the first compound, a Lewis acid and developer CIBA-GEIGY CORPORATION (US) 1991-06-18 US disclosed
EP-0415885-A1 Bis-Phthalideactones, process for their preparation, and their use in recording materials CIBA-GEIGY AG (CH) 1991-03-06 EP disclosed
EP-0373110-A2 Pressure-sensitive or heat-sensitive recording material CIBA-GEIGY AG (CH) 1990-06-13 EP disclosed
US-4467024-A Process for the production of thermo-developable type diazo copying material RICOH CO., LTD. (JP) 1984-08-21 US disclosed
US-4416967-A SUBSTRATE, PRECOAT LAYER OF SILICA AND COPOLYMER OF ACRYLIC, OXY, RICOH CO., LTD. (JP) 1983-11-22 US disclosed
US-4400456-A FATTY ACID AMIDE COLOR ASSIST, HIGH DENSITY IMAGES RICOH CO., LTD. (JP) 1983-08-23 US disclosed
JP-S57189130-A MANUFACTURE OF HEAT DEVELOPABLE TYPE DIAZO COPYING MATERIAL RICOH CO LTD 1982-11-20 JP disclosed
US-4304831-A ELECTROGRAPHY; COPIES RICOH CO., LTD. (JP) 1981-12-08 US disclosed