Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | FADS1 | O60427 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL865075 | 1.00 | TNF (0.39) | TNFNOD1RAB9APIK3CDFADS1 | |
| Formic Acid SCHEMBL863792 | 0.84 | PIK3CD (0.40) | PIK3CDMKNK2PIK3R2PIK3CGEGFR | |
| Formic Acid SCHEMBL863791 | 0.84 | PIK3CD (0.40) | PIK3CDMKNK2PIK3R2PIK3CGEGFR | |
| Formic Acid SCHEMBL865073 | 0.83 | RAB9A (0.39) | TNFNOD1RAB9APIK3CDFADS1 | |
| SCHEMBL863479 | 0.79 | RAB9A (0.45) | TNFNOD1RAB9APIK3CDFADS1 | |
| SCHEMBL863478 | 0.79 | RAB9A (0.45) | TNFNOD1RAB9APIK3CDFADS1 | |
| Hydrochloric Acid SCHEMBL864071 | 0.74 | IRAK4 (0.38) | PIK3CDRPS6KB1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL864070 | 0.74 | IRAK4 (0.38) | PIK3CDRPS6KB1ALDH1A1LMNA | |
| SCHEMBL865314 | 0.71 | RAB9A (0.42) | TNFNOD1RAB9APIK3CDFADS1 | |
| SCHEMBL14574704 | 0.71 | TNF (0.40) | TNFNOD1RAB9APIK3CDFADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513284-B2 | Fused pyridine and pyrazine derivatives as kinase inhibitors | UCB PHARMA, S.A. (BE) | 2013-08-20 | — | — | US | disclosed |
| US-20120077815-A1 | Fused Pyridine And Pyrazine Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077815-A1 | Fused Pyridine And Pyrazine Derivatives As Kinase Inhibitors | PDPK1, PDXK, PIK3CA | TNF 1114/4885NOD1 374/4885RAB9A 1316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.