Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499343 | 0.97 | LMNA (0.56) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL18528182 | 0.85 | KDM4E (0.47) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL8887277 | 0.81 | USP2 (0.52) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL18328051 | 0.78 | ALDH1A1 (0.40) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL8643035 | 0.77 | ALDH1A1 (0.49) | LMNAKMT2AMEN1KDM4EMAPT | |
| SCHEMBL22289985 | 0.75 | MAPT (0.54) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL2394139 | 0.74 | KDM4E (0.57) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL9803048 | 0.73 | ALDH1A1 (0.56) | LMNAKMT2ANPC1MEN1RAB9A | |
| SCHEMBL27353018 | 0.73 | CA12 (0.49) | NPC1RAB9AKDM4EBRD4MAPT | |
| SCHEMBL30995620 | 0.73 | CA12 (0.49) | NPC1RAB9AKDM4EBRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854256-A | Quinuclidine derivatives | PFIZER INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5698568-A | Quinuclidine derivatives | PFIZER INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5641786-A | Quinuclidine derivatives | LOWE III JOHN ADAMS (US) | 1997-06-24 | — | — | US | disclosed |
| US-5422354-A | Quinuclidine derivatives | PFIZER INC (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0540526-B1 | QUINUCLIDINE DERIVATIVES | PFIZER (US) | 1994-12-28 | — | — | EP | disclosed |
| WO-1992001688-A1 | QUINUCLIDINE DERIVATIVES | PFIZER INC. (US) | 1992-02-06 | — | — | WO | disclosed |