Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654001 | 0.86 | ALDH1A1 (0.48) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL2786303 | 0.74 | HPGD (0.55) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL1070520 | 0.72 | CYP3A4 (0.77) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL8651087 | 0.70 | HPGD (0.42) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL6517570 | 0.64 | POLB (0.51) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL12521788 | 0.61 | CYP3A4 (0.75) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL6517578 | 0.61 | HPGD (0.51) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL2786497 | 0.60 | HPGD (0.67) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL12521810 | 0.59 | CYP3A4 (0.61) | HPGDMEN1ALDH1A1KMT2ATSHR | |
| SCHEMBL11088249 | 0.58 | CYP3A4 (0.79) | HPGDMEN1ALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814647-A | ANTICARCINOGENIC AGENTS, ANTIDIABETIC AGENTS AND MENSTRUAL DISORDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-09-29 | — | — | US | claimed |
| US-5708012-A | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus | SANKYO COMPANY, LIMITED (JP) | 1998-01-13 | — | — | US | claimed |
| US-5814647-A | ANTICARCINOGENIC AGENTS, ANTIDIABETIC AGENTS AND MENSTRUAL DISORDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-09-29 | — | — | US | disclosed |
| US-5708012-A | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus | SANKYO COMPANY, LIMITED (JP) | 1998-01-13 | — | — | US | disclosed |