Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.56 |
| ▸ | GSR | P00390 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | GRM8 | O00222 | 2/20 | 0.56 |
| ▸ | GRM6 | O15303 | 2/20 | 0.56 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.56 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8648790 | 1.00 | KMT2A (0.59) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL27970765 | 0.87 | SLC1A1 (0.60) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL7294293 | 0.87 | SLC1A1 (0.60) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL28015254 | 0.87 | SLC1A1 (0.60) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL28203156 | 0.87 | SLC1A1 (0.60) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL27563225 | 0.85 | SLC1A1 (0.58) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL2917216 | 0.85 | SLC1A1 (0.58) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL7158243 | 0.85 | GSR (0.58) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL4406473 | 0.84 | KMT2A (0.55) | KMT2AALOX15BLMPMP22SLC1A1 | |
| SCHEMBL5076321 | 0.83 | GSR (0.56) | KMT2AALOX15BLMPMP22SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807688-A | ANTIBODY DIRECTED ANZYME PRODRUG THERAPY | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| EP-0745673-A2 | Catalytic antibody regulated prodrug therapy | ZENECA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |