Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.39 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653867 | 0.93 | PTPN1 (0.36) | ESR1ESR2HSD17B3PPARGPTPN1 | |
| SCHEMBL8655703 | 0.78 | ESR1 (0.43) | ESR1ESR2CYP2D6 | |
| SCHEMBL8656916 | 0.72 | ESR1 (0.42) | ESR1ESR2POLHHSD17B3USP7 | |
| SCHEMBL8654530 | 0.65 | PTPN1 (0.37) | ESR1ESR2HSD17B3PPARGPTPN1 | |
| SCHEMBL8635613 | 0.62 | MEN1 (0.54) | POLHHSD17B3PTPN1ACP1KDM4E | |
| SCHEMBL8638845 | 0.62 | HSD17B3 (0.56) | ESR1ESR2POLHHSD17B3PPARG | |
| SCHEMBL8657893 | 0.61 | ESR1 (0.47) | ESR1ESR2USP7PTPN1ACP1 | |
| SCHEMBL8383149 | 0.59 | HSD17B3 (0.65) | ESR1ESR2HSD17B3PPARGKDM4E | |
| SCHEMBL5729783 | 0.59 | ESR1 (0.48) | ESR1ESR2USP7KDM4EGMNN | |
| SCHEMBL5274700 | 0.56 | ESR1 (0.53) | ESR1ESR2USP7KDM4EGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516257-B1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AG (DE) | 1998-08-05 | — | — | EP | claimed |