Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 4/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303402 | 0.84 | KDM4E (0.55) | HRH4ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL31513837 | 0.84 | HRH4 (0.52) | HRH4ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL2134591 | 0.83 | FLT3 (0.58) | ALDH1A1HSD17B10KDM4EHPGDMEN1 | |
| SCHEMBL30310659 | 0.83 | HRH4 (0.55) | HRH4ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL915460 | 0.83 | HRH4 (0.55) | HRH4ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL2323348 | 0.81 | FLT3 (0.59) | HRH4ULK1KIF11CYP1A2GAA | |
| SCHEMBL217459 | 0.81 | FLT3 (0.66) | HRH4KDM4EMEN1KMT2AULK1 | |
| SCHEMBL2205092 | 0.81 | HRH4 (0.56) | HRH4ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL5568273 | 0.81 | FLT3 (0.59) | HRH4ULK1KIF11CYP1A2GAA | |
| SCHEMBL31156446 | 0.80 | HRH4 (0.57) | HRH4ALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377717-B2 | Farnesoid X receptor agonists and uses thereof | METACRINE, INC. (US) | 2019-08-13 | — | — | US | disclosed |
| US-20180251429-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. | 2018-09-06 | — | — | US | disclosed |
| EP-3350166-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | Metacrine, Inc. (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2017049177-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
| WO-2017049177-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
| EP-0678090-B1 | PIPERAZINE DERIVATIVES | WYETH JOHN & BROTHER LTD (GB) | 1998-10-14 | — | — | EP | disclosed |
| US-5627177-A | Piperazine derivatives | JOHN WYETH & BROTHER, LTD. (GB) | 1997-05-06 | — | — | US | disclosed |
| EP-0678090-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-10-25 | — | — | EP | disclosed |
| WO-1994015919-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1994-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180251429-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | NR1H4, NR1H2, NR1H3 | HRH4 590/4885ALDH1A1 2205/4885HSD17B10 308/4885 |
| US-10377717-B2 | Farnesoid X receptor agonists and uses thereof | NR1H4, NR1H2, NR1H3 | HRH4 590/4885ALDH1A1 2205/4885HSD17B10 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.