SCHEMBL8655810

SCHEMBL8655810

O=C(NC(=O)c1c(F)cccc1F)Nc1cc(Cl)c(OCc2ccc(Cl)cc2)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
PYGL P06737 2/20 0.44
GAA P10253 3/20 0.44
PTGER1 P34995 1/20 0.42
MAPT P10636 2/20 0.42
USP2 O75604 1/20 0.42
ALOX15 P16050 1/20 0.42
NPC1 O15118 4/20 0.42
RAB9A P51151 3/20 0.42
POLB P06746 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
ITGB1 P05556 1/20 0.41
ITGA4 P13612 1/20 0.41
CNR1 P21554 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11229534 0.92 PYGL (0.49) MEN1KMT2APYGLPTGER1MAPT
SCHEMBL11242520 0.89 PTGER1 (0.45) MEN1KMT2AGAAPTGER1MAPT
SCHEMBL11236591 0.89 MEN1 (0.44) MEN1KMT2APYGLMAPTUSP2
SCHEMBL11244545 0.88 MAPT (0.49) MEN1KMT2APYGLGAAMAPT
SCHEMBL11233119 0.87 GCGR (0.49) MEN1KMT2AGAAPTGER1MAPT
SCHEMBL17036167 0.85 MEN1 (0.53) MEN1KMT2APYGLGAAMAPT
SCHEMBL11381816 0.84 NPC1 (0.50) MEN1KMT2AGAANPC1RAB9A
SCHEMBL4152345 0.83 MEN1 (0.51) MEN1KMT2AGAAMAPTUSP2
SCHEMBL11385909 0.83 ALDH1A1 (0.52) MEN1KMT2APYGLGAAPTGER1
SCHEMBL10815707 0.83 CNR1 (0.50) MEN1KMT2AMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59020265-A None JP disclosed
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
JP-S5920265-A BENZOYLUREA DERIVATIVE, ITS PREPARATION AND INSECTICIDAL AND MITICIDAL AGENT KUMIAI CHEM IND CO LTD 1984-02-01 JP disclosed
US-4350706-A MITICIDES, LARVICIDES DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1982-09-21 US disclosed