Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.58 |
| ▸ | MAOB | P27338 | 6/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | SDHA | P31040 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CALML3 | P27482 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8656064 | 0.89 | MAOB (0.58) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL8641554 | 0.89 | MAOA (0.46) | MAOAMAOBCYP2C19PTGS1SDHA | |
| SCHEMBL8657837 | 0.89 | MAOB (0.46) | MAOAMAOBCYP2C19PTGS1SDHA | |
| SCHEMBL8656846 | 0.88 | MAOA (0.45) | MAOAMAOBCYP2C19PTGS1SDHA | |
| SCHEMBL8655743 | 0.86 | MAOA (0.44) | MAOAMAOBCYP2C19PTGS1SDHA | |
| SCHEMBL8660603 | 0.86 | MAOA (0.44) | MAOAMAOBCYP2C19PTGS1SDHA | |
| SCHEMBL8654289 | 0.86 | LMNA (0.46) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL8654163 | 0.86 | F10 (0.44) | MAOAMAOBCYP2C19PTGS1SDHA | |
| SCHEMBL8642618 | 0.86 | F10 (0.44) | MAOAMAOBCYP2C19PTGS1SDHA | |
| SCHEMBL8656769 | 0.86 | MAOA (0.44) | MAOAMAOBCYP2C19PTGS1SDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858453-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | AstraZeneca AB (SE) | 1998-08-19 | — | — | EP | claimed |
| WO-1997014690-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZENECA LIMITED (GB) | 1997-04-24 | — | — | WO | claimed |
| EP-0858453-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | AstraZeneca AB (SE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014690-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZENECA LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |