Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.43 |
| ▸ | F10 | P00742 | 4/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.37 |
| ▸ | FEN1 | P39748 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661240 | 0.90 | PTGS2 (0.42) | PTGS2PTGS1F10PTGES2CA12 | |
| SCHEMBL8662987 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1F10ALOX5APFEN1 | |
| SCHEMBL8659420 | 0.88 | PTGS2 (0.55) | PTGS2PTGS1F10PTGES2ALOX5AP | |
| SCHEMBL8661053 | 0.88 | PTGS2 (0.40) | PTGS2PTGS1F10PTGES2CA12 | |
| SCHEMBL8661800 | 0.88 | PTGS2 (0.47) | PTGS2PTGS1F10ALOX5APFEN1 | |
| SCHEMBL8656182 | 0.87 | PTGS2 (0.38) | PTGS2PTGS1F10PTGES2ALOX5AP | |
| SCHEMBL8658005 | 0.86 | PTGES2 (0.53) | PTGS2PTGS1F10PTGES2ALOX5AP | |
| SCHEMBL8660156 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1F10PTGES2ALOX5AP | |
| SCHEMBL8658040 | 0.86 | PTGS2 (0.45) | PTGS2PTGS1F10PTGES2ALOX5AP | |
| SCHEMBL8661262 | 0.86 | PTGS2 (0.49) | PTGS2PTGS1F10PTGES2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |