SCHEMBL8656228

SCHEMBL8656228

O=C(NC(=O)c1ccccc1Cl)Nc1c(Cl)cc(Oc2ccc(Cl)cc2Br)c(Cl)c1Cl

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.53
PYGL P06737 7/20 0.49
PNLIP P16233 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
POLB P06746 1/20 0.43
PKM P14618 1/20 0.43
TDP1 Q9NUW8 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ATM Q13315 1/20 0.41
PARP1 P09874 1/20 0.41
PARG Q86W56 1/20 0.41
STK39 Q9UEW8 1/20 0.39
PLCG2 P16885 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8659728 0.92 PYGL (0.49) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8657598 0.92 GCGR (0.50) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8659354 0.91 LMNA (0.47) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8660806 0.90 GCGR (0.61) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8659530 0.89 MAPT (0.42) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8657616 0.87 GCGR (0.48) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8659878 0.85 MEN1 (0.43) GCGRNPC1POLBMEN1KMT2A
SCHEMBL8657789 0.85 MEN1 (0.47) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8666135 0.84 GCGR (0.53) GCGRPYGLPNLIPNPC1RAB9A
SCHEMBL8661424 0.84 GCGR (0.49) GCGRPYGLPNLIPNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed