Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9850808 | 0.87 | MAPT (0.47) | PTGDR2IRAK4CASP1MAP2K1HTT | |
| SCHEMBL29577607 | 0.79 | PTGDR2 (0.48) | PTGDR2MMP2KDM4EMAPTKMT2A | |
| SCHEMBL15145964 | 0.78 | PTGDR2 (0.44) | PTGDR2MMP2CASP1HTTKDM4E | |
| SCHEMBL10603931 | 0.78 | KDM4E (0.42) | PARP1HTTKDM4EMEN1NR1I2 | |
| SCHEMBL13126996 | 0.77 | TUBB1 (0.51) | PTGDR2MEN1MAPTHTR2BKMT2A | |
| SCHEMBL27540093 | 0.77 | KMT2A (0.45) | PTGDR2HTTKDM4EMEN1NR1I2 | |
| SCHEMBL12505492 | 0.77 | NPC1 (0.47) | PTGDR2IRAK4HTTKDM4EMEN1 | |
| SCHEMBL1619495 | 0.75 | PTGDR2 (0.44) | PTGDR2MMP2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8981628 | 0.75 | KDM4E (0.47) | HTTKDM4EMEN1NR1I2LMNA | |
| SCHEMBL2312770 | 0.74 | IKBKB (0.49) | PARP1CASP1PARP2PARP15PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |