Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125585 | 0.92 | HRH3 (0.42) | PTGDR2HRH3USP30CYP11B1CYP11B2 | |
| SCHEMBL22781839 | 0.87 | CYP19A1 (0.43) | PTGDR2HRH3CYP11B1CYP11B2AR | |
| SCHEMBL30232819 | 0.86 | PTGDR2 (0.43) | PTGDR2HRH3USP30CYP11B1CYP11B2 | |
| SCHEMBL29577607 | 0.84 | PTGDR2 (0.48) | PTGDR2CYP11B1CYP11B2ARCYP19A1 | |
| SCHEMBL1714334 | 0.83 | HRH3 (0.43) | PTGDR2HRH3USP30CYP11B1CYP11B2 | |
| SCHEMBL9969445 | 0.83 | SLC6A9 (0.47) | PTGDR2HRH3USP30CYP11B1AR | |
| SCHEMBL3119850 | 0.83 | HRH3 (0.40) | PTGDR2HRH3USP30CYP11B1CYP11B2 | |
| SCHEMBL5314540 | 0.83 | HRH3 (0.40) | PTGDR2HRH3USP30CYP11B1CYP11B2 | |
| SCHEMBL12460722 | 0.83 | HRH3 (0.43) | PTGDR2HRH3USP30CYP11B1CYP11B2 | |
| SCHEMBL3121798 | 0.82 | HRH3 (0.42) | PTGDR2HRH3USP30CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928225-B2 | Oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2011-04-19 | — | — | US | disclosed |
| US-20100222335-A1 | Process For The Preparation Of N,N'-Disubstituted Oxabispidines | ASTRAZENECA AB (SE) | 2010-09-02 | — | — | US | disclosed |
| US-20090054422-A1 | New Oxabispidine Compounds For The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| CN-101243093-A | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2008-08-13 | — | — | CN | disclosed |
| CN-101203521-A | Process for the preparation of N,N'-disubstituted oxabispidines | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | CN | disclosed |
| EP-1915380-A1 | PROCESS FOR THE PREPARATION OF N,N´- DISUBSTITUTED OXABISPIDINES | AstraZeneca AB (SE) | 2008-04-30 | — | — | EP | disclosed |
| WO-2006137770-A1 | PROCESS FOR THE PREPARATION OF N,N´- DISUBSTITUTED OXABISPIDINES | ASTRAZENECA AB (SE) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222335-A1 | Process For The Preparation Of N,N'-Disubstituted Oxabispidines | ADH1C, ADH5, ADH1A | PTGDR2 934/4885HRH3 494/4885USP30 3797/4885 |
| US-20090054422-A1 | New Oxabispidine Compounds For The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | PTGDR2 1553/4885HRH3 448/4885USP30 3818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.