Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.39 |
| ▸ | FEN1 | P39748 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661969 | 0.90 | PTGES2 (0.50) | PTGES2F10ADORA2AADORA1 | |
| SCHEMBL8661361 | 0.88 | MAPT (0.49) | MAPTPTGS1KMT2AF10NPC1 | |
| SCHEMBL8659866 | 0.87 | PTGS2 (0.45) | P2RX3MAPTPTGS1PTGS2USP2 | |
| SCHEMBL8660193 | 0.86 | PTGS2 (0.44) | PTGES2MAPTPTGS1PTGS2F10 | |
| SCHEMBL8661079 | 0.85 | PTGS2 (0.39) | MAPTPTGS1PTGS2F10ALOX5AP | |
| SCHEMBL8657401 | 0.85 | PTGS2 (0.43) | P2RX3MAPTPTGS1PTGS2USP2 | |
| SCHEMBL8657899 | 0.85 | CA9 (0.47) | MAPTPTGS1PTGS2KMT2AALOX5AP | |
| SCHEMBL8661477 | 0.84 | PTGS2 (0.54) | PTGES2PTGS1PTGS2F10ALOX5AP | |
| SCHEMBL8657860 | 0.84 | PTGS2 (0.43) | PTGES2MAPTPTGS1PTGS2USP2 | |
| SCHEMBL8660480 | 0.82 | ALOX5AP (0.41) | PTGS1PTGS2KMT2AF10ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |