Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.38 |
| ▸ | FEN1 | P39748 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660193 | 0.89 | PTGS2 (0.44) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL8663491 | 0.88 | ALOX5AP (0.41) | PTGS2PTGS1ALOX5APFEN1CA2 | |
| SCHEMBL8657899 | 0.88 | CA9 (0.47) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL8661432 | 0.87 | ALOX5AP (0.40) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8661477 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8661468 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL8657401 | 0.85 | PTGS2 (0.43) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL8657919 | 0.85 | PTGS1 (0.39) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8656757 | 0.85 | PTGES2 (0.41) | PTGS2PTGS1ALOX5APFEN1MAPT | |
| SCHEMBL8659866 | 0.85 | PTGS2 (0.45) | PTGS2PTGS1ALOX5APFEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |