Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AOC2 | O75106 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654063 | 0.88 | MAPT (0.47) | MAPTPDE10ATLR7HDAC6SMN1; SMN2 | |
| SCHEMBL8088160 | 0.85 | MAPT (0.65) | MAPTAOC2PDE10ATLR7HDAC6 | |
| SCHEMBL15857985 | 0.78 | RPS6KA5 (0.40) | MAPTAOC2PDE10ASMN1; SMN2NPC1 | |
| SCHEMBL10388000 | 0.77 | MAPT (0.47) | MAPTPDE10ATLR7HDAC6SMN1; SMN2 | |
| SCHEMBL10281995 | 0.76 | MAPT (0.42) | MAPTAOC2PDE10AHDAC6SMN1; SMN2 | |
| SCHEMBL10388001 | 0.75 | MAPT (0.49) | MAPTPDE10ATLR7HDAC6SMN1; SMN2 | |
| SCHEMBL9690915 | 0.75 | ATM (0.47) | MAPTPDE10AHDAC6SMN1; SMN2NPC1 | |
| SCHEMBL17897213 | 0.74 | LMNA (0.44) | AOC2PDE10ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL18306494 | 0.74 | NPC1 (0.45) | MAPTAOC2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10313053 | 0.74 | SMN1; SMN2 (0.44) | MAPTAOC2PDE10ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680967-B1 | Erythromycin derivatives, their process of preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (FR) | 1998-10-14 | — | — | EP | disclosed |
| EP-0680967-A1 | Erythromycin derivatives, their process of preparation and their use as medicaments | ROUSSEL-UCLAF (FR) | 1995-11-08 | — | — | EP | disclosed |