Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL7177842 | 0.94 | PTGS2 (0.53) | PTGS2PTGS1MEN1KMT2AALDH1A1 | |
| SCHEMBL8657378 | 0.91 | MEN1 (0.53) | PTGS2PTGS1MEN1KMT2ASTAT3 | |
| SCHEMBL8659675 | 0.90 | STAT3 (0.58) | PTGS2PTGS1KMT2AALDH1A1LMNA | |
| SCHEMBL8659946 | 0.90 | PTGS2 (0.56) | PTGS2KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8659494 | 0.87 | PTGS2 (0.58) | PTGS2PTGS1KMT2AALDH1A1LMNA | |
| SCHEMBL8657813 | 0.87 | MEN1 (0.50) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL8660532 | 0.87 | STAT3 (0.58) | PTGS2ALDH1A1LMNASTAT3ACLY | |
| SCHEMBL8659105 | 0.86 | PTGS2 (0.55) | PTGS2MEN1KMT2AALDH1A1STAT3 | |
| SCHEMBL8660021 | 0.86 | PTGS2 (0.60) | PTGS2PTGS1MEN1KMT2AALDH1A1 | |
| SCHEMBL8657396 | 0.86 | PTGS2 (0.52) | PTGS2PTGS1MEN1KMT2ASTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | claimed |
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |