Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 4/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8656212 | 0.92 | PTGES2 (0.52) | STAT3SLC40A1ACLYCRHBPCRHR2 | |
| SCHEMBL8659510 | 0.90 | STAT3 (0.49) | PTGS2STAT3SLC40A1ERBB2HSP90AA1 | |
| SCHEMBL8659454 | 0.89 | ERBB2 (0.52) | STAT3SLC40A1ERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL8660201 | 0.89 | STAT3 (0.60) | STAT3SLC40A1ERBB2HSP90AA1HSP90AB1 | |
| SCHEMBL8658420 | 0.89 | PTGS2 (0.56) | PTGS2PTGS1STAT3SLC40A1ACLY | |
| SCHEMBL8663418 | 0.88 | STAT3 (0.59) | PTGS2PTGS1STAT3MEN1TSHR | |
| SCHEMBL8659295 | 0.88 | SLC40A1 (0.51) | SLC40A1ERBB2HSP90AA1HSP90AB1ACLY | |
| SCHEMBL8661296 | 0.88 | SLC40A1 (0.48) | SLC40A1ERBB2HSP90AA1HSP90AB1ACLY | |
| SCHEMBL8659644 | 0.87 | NAT1 (0.55) | SLC40A1ERBB2HSP90AA1HSP90AB1ACLY | |
| SCHEMBL8657426 | 0.87 | SCN9A (0.46) | STAT3SLC40A1ACLYCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | claimed |
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |