Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 4/20 | 0.62 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.59 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.56 |
| ▸ | TUBB | P07437 | 2/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660187 | 0.89 | STAT3 (0.62) | STAT3PTGES2KEAP1NFE2L2MCOLN3 | |
| SCHEMBL8649422 | 0.88 | PTGES2 (0.56) | STAT3PTGES2KEAP1NFE2L2TUBB4A | |
| SCHEMBL28452095 | 0.85 | SLC22A12 (0.74) | STAT3PTGES2KEAP1NFE2L2PGR | |
| SCHEMBL8659936 | 0.85 | STAT3 (0.58) | STAT3PTGES2KEAP1NFE2L2TUBB4A | |
| SCHEMBL2518687 | 0.85 | STAT3 (0.80) | STAT3KEAP1NFE2L2MCOLN3CA12 | |
| SCHEMBL8662980 | 0.85 | STAT3 (0.80) | STAT3KEAP1NFE2L2MCOLN3CA12 | |
| SCHEMBL21708292 | 0.83 | KEAP1 (0.60) | STAT3PTGES2KEAP1NFE2L2MCOLN3 | |
| SCHEMBL8660547 | 0.82 | LMNA (0.71) | STAT3MCOLN3CA12CA2LMNA | |
| SCHEMBL21708334 | 0.81 | STAT3 (0.57) | STAT3PTGES2KEAP1NFE2L2TUBB4A | |
| SCHEMBL8663502 | 0.81 | PTGES2 (0.51) | STAT3PTGES2KEAP1NFE2L2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |