Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187607 | 0.98 | MAPK1 (0.64) | MAPK1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL12233268 | 0.80 | MAPK1 (0.53) | MAPK1KDM4EMAPTALDH1A1RECQL | |
| SCHEMBL8439255 | 0.80 | KDM4E (0.70) | MAPK1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL28775271 | 0.79 | KDM4E (0.53) | MAPK1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL6876786 | 0.78 | GAA (0.58) | MAPK1KDM4EGAAL3MBTL1ALDH1A1 | |
| SCHEMBL18989534 | 0.78 | ALDH1A1 (0.46) | MAPK1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL638043 | 0.78 | MAPK1 (1.00) | MAPK1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL638044 | 0.78 | MAPK1 (1.00) | MAPK1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL15331425 | 0.77 | MAPK1 (0.76) | MAPK1KDM4EGAAL3MBTL1MAPT | |
| SCHEMBL18990660 | 0.77 | KDM4E (0.65) | MAPK1KDM4EGAAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728686-A | TREATMENT OF MUSCULAR DYSTROPHY | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |
| CN-1158855-A | Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as pharmacueticals | HOECHST AG (DE) | 1997-09-10 | — | — | CN | disclosed |