Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.69 |
| ▸ | CA9 | Q16790 | 2/20 | 0.69 |
| ▸ | CA1 | P00915 | 2/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654024 | 0.85 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL8653987 | 0.83 | PTGS2 (0.68) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL8653562 | 0.82 | PTGS2 (0.72) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL8386227 | 0.82 | CA2 (0.61) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL8383922 | 0.82 | PTGS2 (0.64) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL8385416 | 0.82 | CA2 (0.64) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL214496 | 0.79 | PTGS2 (0.59) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL6721929 | 0.79 | PTGS2 (0.50) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL6735159 | 0.78 | PTGS2 (0.49) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL8651288 | 0.77 | PTGS2 (0.68) | CA2CA9CA12PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-B1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1998-10-07 | — | — | EP | disclosed |
| US-5663180-A | ANTIARTHRITIC, ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| US-5420287-A | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1995-05-30 | — | — | US | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |
| US-5344991-A | Sulfonyl or sulfamyl derivatives for treatment of arthritis and pain | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | disclosed |