Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 10/20 | 0.46 |
| ▸ | RARG | P13631 | 10/20 | 0.46 |
| ▸ | RARA | P10276 | 9/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.35 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654860 | 0.84 | CYP3A4 (0.54) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL27304274 | 0.84 | RARB (0.62) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL7648981 | 0.76 | RARB (0.61) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL7654342 | 0.76 | CYP3A4 (0.53) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9817722 | 0.76 | RARA (0.63) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL7650773 | 0.74 | RARA (0.40) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL7650870 | 0.74 | CYP3A4 (0.35) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8580705 | 0.72 | RARB (0.65) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8037152 | 0.71 | RARA (0.52) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL7659037 | 0.71 | CYP3A4 (0.46) | RARBRARGRARACYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750693-A | THIOCHROMANYL OR CHROMANYL COMPOUNDS AS ANTICARCINOGINIC AGENTS, SKIN DISORDERS AND ATHEROSCLEROSIS | ALLERGAN (US) | 1998-05-12 | — | — | US | disclosed |
| US-5677451-A | CONTROLLING CELL DIFFERENTIATION; SKIN DISORDERS; ANTICANCER AGENTS | ALLERGAN (US) | 1997-10-14 | — | — | US | disclosed |