SCHEMBL8660043

SCHEMBL8660043

Cc1ccc(Oc2cc(C)c(NC(=O)NC(=O)c3ccccc3Cl)c(C)c2C)c(C)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.55
MEN1 O00255 3/20 0.55
PYGL P06737 4/20 0.51
GCGR P47871 1/20 0.47
RAB9A P51151 3/20 0.46
GAA P10253 2/20 0.44
MAPT P10636 2/20 0.44
NPC1 O15118 2/20 0.44
POLB P06746 2/20 0.44
ALDH1A1 P00352 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
PKM P14618 1/20 0.44
KDM4E B2RXH2 1/20 0.44
TDP1 Q9NUW8 1/20 0.40
ATM Q13315 1/20 0.40
PCTP Q9UKL6 1/20 0.40
TP53 P04637 1/20 0.39
KCNK3 O14649 1/20 0.39
KCNK9 Q9NPC2 1/20 0.39
GHSR Q92847 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8673485 0.93 KMT2A (0.54) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8657550 0.88 GCGR (0.57) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8661424 0.85 GCGR (0.49) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8657639 0.83 GCGR (0.48) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8659544 0.82 PYGL (0.48) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8658014 0.82 PYGL (0.52) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8657591 0.80 GCGR (0.56) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL10492149 0.80 PYGL (0.50) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8665614 0.80 GCGR (0.56) KMT2AMEN1PYGLGCGRRAB9A
SCHEMBL8660807 0.79 PNLIP (0.50) KMT2AMEN1PYGLGCGRRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
US-4873264-A Novel pesticidal 1-(alkyl-phenoxy-aryl)-3-benzoyl ureas and process for preparation RHONE-POULENC NEDERLANDS B.V. (NL) 1989-10-10 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
EP-0098158-A1 Pesticidal 1-(alkyl-phenoxyaryl)-3-benzoyl ureas and process for preparation UNION CARBIDE CORPORATION (US) 1984-01-11 EP disclosed