SCHEMBL8660073

SCHEMBL8660073

C=CCc1cc2c(c(CC=C)c1O)CCC(=O)N2C

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.36
GAA P10253 2/20 0.36
GLA P06280 1/20 0.36
BRD4 O60885 2/20 0.34
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
MAPT P10636 2/20 0.33
POLB P06746 2/20 0.32
MAPK1 P28482 1/20 0.31
HTR1A P08908 1/20 0.31
HPGD P15428 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HSD17B10 Q99714 1/20 0.31
ALOX5 P09917 1/20 0.30
PTGS1 P23219 1/20 0.30
PTGS2 P35354 1/20 0.30
ELANE P08246 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8660070 0.85 KDM4E (0.34) KDM4EGAAGLAMEN1KMT2A
SCHEMBL7845505 0.84 KDM4E (0.32) KDM4EGAAGLAMAPT
SCHEMBL7854212 0.84 KDM4E (0.36) KDM4EGAAGLAMEN1KMT2A
SCHEMBL7854439 0.82 KDM4E (0.33) KDM4EGAAGLAMEN1KMT2A
SCHEMBL7845458 0.81 MGLL (0.41) KDM4EGAAGLAPTGS1PTGS2
SCHEMBL7853643 0.81 KDM4E (0.32) KDM4EGAAGLA
SCHEMBL7844608 0.81 KDM4E (0.30) KDM4EGAAGLA
SCHEMBL7854065 0.81 NPSR1 (0.32) KDM4EGAAGLA
SCHEMBL7848198 0.81 PTPN1 (0.38) KDM4EGAAGLAMEN1KMT2A
SCHEMBL7852043 0.80 MEN1 (0.35) KDM4EGAAGLAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5786367-A OXYGEN SCAVENGERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-07-28 US disclosed