SCHEMBL7852043

SCHEMBL7852043

C=CCc1cc2c(c(CC=C)c1O)CCC(=O)N2CC(=O)O

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
LOXL2 Q9Y4K0 1/20 0.34
TSHR P16473 2/20 0.32
HTT P42858 2/20 0.32
ALDH1A1 P00352 4/20 0.31
KDM4E B2RXH2 3/20 0.31
GAA P10253 2/20 0.31
GLA P06280 1/20 0.31
EGLN1 Q9GZT9 1/20 0.30
LMNA P02545 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7855481 0.99 MEN1 (0.34) MEN1KMT2ALOXL2TSHRHTT
SCHEMBL7855486 0.99 MEN1 (0.34) MEN1KMT2ALOXL2TSHRHTT
SCHEMBL7852202 0.89 KDM4E (0.31) MEN1KMT2AALDH1A1KDM4EGAA
SCHEMBL7855483 0.88 ALDH1A1 (0.31) HTTALDH1A1KDM4EGAAGLA
SCHEMBL7854540 0.85 LMNA (0.42) MEN1KMT2ALOXL2HTTALDH1A1
SCHEMBL7845505 0.84 KDM4E (0.32) LOXL2KDM4EGAAGLA
SCHEMBL7855653 0.83 POLB (0.36) MEN1KMT2ATSHRALDH1A1EGLN1
SCHEMBL7854439 0.82 KDM4E (0.33) MEN1KMT2AALDH1A1KDM4EGAA
SCHEMBL7854334 0.82 PTGS1 (0.39) MEN1KMT2AHTTALDH1A1KDM4E
SCHEMBL7844608 0.81 KDM4E (0.30) KDM4EGAAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1084330-C Cydic amide derivatives OTSUKA PHARMA CO LTD (JP) 2002-05-08 CN disclosed
EP-0719258-B1 CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS OTSUKA PHARMA CO LTD (JP) 2001-10-31 EP disclosed
US-5786367-A OXYGEN SCAVENGERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-07-28 US disclosed
CN-1130377-A Cyclic amide derivatives OTSUKA PHARMA CO LTD (JP) 1996-09-04 CN disclosed
EP-0719258-A1 CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-07-03 EP disclosed
WO-1996002508-A1 CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-02-01 WO disclosed