Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 18/20 | 0.58 |
| ▸ | UBA3 | Q8TBC4 | 16/20 | 0.58 |
| ▸ | UBA1 | P22314 | 1/20 | 0.37 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL866594 | 1.00 | NAE1 (0.58) | NAE1UBA3UBA1UBA6SAE1 | |
| SCHEMBL867174 | 0.83 | NAE1 (0.44) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL867353 | 0.83 | NAE1 (0.44) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL866336 | 0.80 | NAE1 (0.42) | NAE1UBA3 | |
| SCHEMBL867053 | 0.79 | NAE1 (0.43) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL865882 | 0.79 | NAE1 (0.43) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL866989 | 0.76 | NAE1 (0.69) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL10184289 | 0.75 | NAE1 (0.63) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL865945 | 0.75 | NAE1 (0.63) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL866908 | 0.74 | NAE1 (0.53) | NAE1UBA3UBA6SAE1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | WANG ZHONG (US) | 2012-03-29 | — | — | US | claimed |
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | WANG ZHONG (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077814-A1 | SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES | NEDD8, NAE1, UBA3 | NAE1 2/4885UBA3 3/4885UBA1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.