UBA3

NEDD8-activating enzyme E1 catalytic subunit · Q8TBC4 · UBA3 on Sugi Atlas →

6,803 patent compounds predicted against UBA3, 4,795 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL782478 SCHEMBL782478 1.00 20/20
SCHEMBL782622 SCHEMBL782622 1.00 20/20
SCHEMBL782657 SCHEMBL782657 1.00 20/20
SCHEMBL782697 SCHEMBL782697 1.00 20/20
SCHEMBL782713 SCHEMBL782713 1.00 20/20
SCHEMBL782727 SCHEMBL782727 1.00 20/20
SCHEMBL782736 SCHEMBL782736 1.00 20/20
SCHEMBL782768 SCHEMBL782768 1.00 20/20
SCHEMBL782791 SCHEMBL782791 1.00 20/20
SCHEMBL782870 SCHEMBL782870 1.00 20/20
SCHEMBL782888 SCHEMBL782888 1.00 20/20
SCHEMBL783481 SCHEMBL783481 1.00 20/20
SCHEMBL783604 SCHEMBL783604 1.00 20/20
SCHEMBL783611 SCHEMBL783611 1.00 20/20
SCHEMBL783653 SCHEMBL783653 1.00 20/20
SCHEMBL789213 SCHEMBL789213 1.00 20/20
SCHEMBL783523 SCHEMBL783523 0.80 20/20
SCHEMBL805370 SCHEMBL805370 0.79 20/20
SCHEMBL782876 SCHEMBL782876 0.78 20/20
SCHEMBL802413 SCHEMBL802413 0.78 20/20

Clinical trials — most relevant to UBA3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients PHASE4NOT_YET_RECRUITING
To Investigate the Efficacy and Safety of UB-421 Monotherapy in HIV-1 Infected Adults PHASE3WITHDRAWN
Olaparib in Patients With HRD Malignant Mesothelioma PHASE2RECRUITING
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma PHASE2SUSPENDED
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma PHASE2WITHDRAWN
Phase II Study of Vandetanib in Individuals With Kidney Cancer PHASE2COMPLETED
A Trial of Anti-CD4 Antibody UB-421 in Combination With Optimized Background Antiretroviral Therapy in Patients With Multi-Drug Resistant HIV-1 Infection PHASE2WITHDRAWN
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers PHASE2NOT_YET_RECRUITING
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma PHASE2WITHDRAWN
A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7248824 in Participants With Angelman Syndrome (AS) PHASE1COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck PHASE1COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis nanUNKNOWN
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1 nanRECRUITING
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome nanRECRUITING
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome nanRECRUITING
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors nanNOT_YET_RECRUITING
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin nanUNKNOWN
HRQoL and Financial Toxicity in Patients With VEXAS Syndrome nanRECRUITING
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma nanCOMPLETED
A Natural History Study of Angelman Syndrome nanRECRUITING
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis nanUNKNOWN
Establishment of a Prospective Clinical-biological Database nanRECRUITING
Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC) nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders nanRECRUITING
Male breAsT cAncer preDisposition Factor: Creation of a Control Cohort 2 nanNOT_YET_RECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Investigation of Copy Number Variations and Genetic Variants in POI nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a UBA3 binder may also engage these)

ProteinNameSimilarity
Q5R4A0 1.000 Q5R4A0 →
Q8C878 1.000 Q8C878 →
Q99MI7 1.000 Q99MI7 →
Q7ZVX6 1.000 Q7ZVX6 →
Q9Z1F9 0.989 Q9Z1F9 →
UBA2 SUMO-activating enzyme subunit 2 0.986 landscape →
Q7ZY60 0.983 Q7ZY60 →
Q642Q1 0.981 Q642Q1 →
Q28GH3 0.977 Q28GH3 →
Q7SXG4 0.973 Q7SXG4 →
A3KMV5 0.973 A3KMV5 →
Q5U300 0.971 Q5U300 →
Q5ZKY2 0.970 Q5ZKY2 →
Q02053 0.970 Q02053 →
Q641Y5 0.970 Q641Y5 →
Q6IQS6 0.970 Q6IQS6 →
Q5R8R4 0.969 Q5R8R4 →
Q8BMF3 0.969 Q8BMF3 →
Q28DS0 0.968 Q28DS0 →
Q9V6U8 0.968 Q9V6U8 →
ME3 NADP-dependent malic enzyme, mitochondrial 0.967 landscape →
UBA1 Ubiquitin-like modifier-activating enzyme 1 0.967 landscape →
Q5RGJ5 0.967 Q5RGJ5 →
Q64514 0.967 Q64514 →
ATG7 Ubiquitin-like modifier-activating enzyme ATG7 0.966 landscape →
A0A1F3 0.966 A0A1F3 →
Q5EA88 0.966 Q5EA88 →
Q29504 0.966 Q29504 →
Q9VE51 0.966 Q9VE51 →
P00337 0.965 P00337 →