SCHEMBL8660992

SCHEMBL8660992

Nc1ccn([C@@]2(CCCCCCO)C[C@H](O)[C@@H](CO)O2)c(=O)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3A Q14432 3/20 0.42
PDE4D Q08499 1/20 0.42
SLC29A1 Q99808 1/20 0.42
LMNA P02545 4/20 0.42
THRB P10828 1/20 0.42
MTOR P42345 1/20 0.42
MDM2 Q00987 1/20 0.42
NCOA1 Q15788 1/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
CACNA1F O60840 2/20 0.38
ALB P02768 2/20 0.38
MAPT P10636 2/20 0.38
CACNA1D Q01668 2/20 0.38
CACNA1S Q13698 2/20 0.38
CACNA1C Q13936 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.33
POLB P06746 2/20 0.33
ALDH1A1 P00352 1/20 0.33
ADRB1 P08588 1/20 0.32
DNMT1 P26358 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2580879 0.93 PDE3A (0.41) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL5155774 0.91 PDE3A (0.41) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL7775023 0.88 PDE3A (0.44) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL4971926 0.87 PDE3A (0.46) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL1962181 0.85 PDE3A (0.45) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL16245248 0.84 PDE3A (0.45) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL31342963 0.84 PDE3A (0.45) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL6408356 0.82 PDE3A (0.43) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL7517670 0.82 PDE3A (0.43) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL771749 0.81 PDE3A (0.42) PDE3APDE4DSLC29A1LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0521111-B1 POLYNUCLEOTIDE CAPTURE ASSAY EMPLOYING IN VITRO AMPLIFICATION CHIRON CORP (US) 1998-11-18 EP disclosed
US-5624802-A OLIGONUCLEIC ACIDS SUCH AS DNA OR RNA WITH SINGLE OR DOUBLE STRANDS HAVING COMB OR FORK STRUCTURES CHIRON CORPORATION (US) 1997-04-29 US disclosed
US-5594118-A Modified N-4 nucleotides for use in amplified nucleic acid hybridization assays CHIRON CORPORATION (US) 1997-01-14 US disclosed
US-5571670-A Nucleic acid probes useful in detecting Chlamydia trachomatis and amplified nucleic acid hybridization assays using same CHIRON CORPORATION (US) 1996-11-05 US disclosed
US-5359100-A Immunoassay CHIRON CORPORATION (US) 1994-10-25 US disclosed
EP-0521111-A4 POLYNUCLEOTIDE CAPTURE ASSAY EMPLOYING IN VITRO AMPLIFICATION CHIRON CORP (US) 1994-06-01 EP disclosed
US-5200314-A POLYNUCLEOTIDE CAPTURE ASSAY EMPLOYING IN VITRO AMPLIFICATION CHIRON CORPORATION (US) 1993-04-06 US disclosed
EP-0521111-A1 POLYNUCLEOTIDE CAPTURE ASSAY EMPLOYING IN VITRO AMPLIFICATION CHIRON CORPORATION (US) 1993-01-07 EP disclosed
EP-0469066-A4 IMPROVED AMPLIFIED NUCLEIC ACID HYBRIDIZATION ASSAYS FOR HBV 1992-07-08 EP disclosed
US-5124246-A Improved hybridization assays for hepatitis B virus, Neissera gonorrhoeae, penicillin and tetracycline resistance in N. gonorrhoeae and Chlamydia trachomatis CHIRON CORPORATION (US) 1992-06-23 US disclosed
EP-0469066-A1 IMPROVED AMPLIFIED NUCLEIC ACID HYBRIDIZATION ASSAYS FOR HBV. CHIRON CORP (US) 1992-02-05 EP disclosed
WO-1991014788-A1 POLYNUCLEOTIDE CAPTURE ASSAY EMPLOYING IN VITRO AMPLIFICATION CHIRON CORPORATION (US) 1991-10-03 WO disclosed
WO-1990013667-A1 IMPROVED AMPLIFIED NUCLEIC ACID HYBRIDIZATION ASSAYS FOR HBV CHIRON CORPORATION (US) 1990-11-15 WO disclosed
WO-1989003891-A1 NUCLEIC ACID MULTIMERS AND AMPLIFIED NUCLEIC ACID HYBRIDIZATION ASSAYS USING SAME CHIRON CORPORATION (US) 1989-05-05 WO disclosed