Sugi Predict

Sugi Predict / Compounds / SCHEMBL16245248

SCHEMBL16245248

SCHEMBL16245248

C=CC[C@]1(n2ccc(N)nc2=O)C[C@H](O)[C@@H](CO)O1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE3A Q14432 3/20 0.45
▸ PDE4D Q08499 1/20 0.45
▸ SLC29A1 Q99808 1/20 0.45
▸ LMNA P02545 4/20 0.42
▸ THRB P10828 1/20 0.42
▸ MTOR P42345 1/20 0.42
▸ MDM2 Q00987 1/20 0.42
▸ NCOA1 Q15788 1/20 0.42
▸ NCOA3 Q9Y6Q9 1/20 0.42
▸ CACNA1F O60840 2/20 0.36
▸ ALB P02768 2/20 0.36
▸ MAPT P10636 2/20 0.36
▸ CACNA1D Q01668 2/20 0.36
▸ CACNA1S Q13698 2/20 0.36
▸ CACNA1C Q13936 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ POLB P06746 2/20 0.33
▸ FGFR1 P11362 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ ADRB1 P08588 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28863011 0.94 PDE3A (0.41) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL31342963 0.89 PDE3A (0.45) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL4971926 0.88 PDE3A (0.46) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL1962181 0.86 PDE3A (0.45) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL7775023 0.85 PDE3A (0.44) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL8660992 0.84 PDE3A (0.42) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL28805006 0.84 PDE3A (0.43) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL6408356 0.83 PDE3A (0.43) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL7517670 0.83 PDE3A (0.43) PDE3APDE4DSLC29A1LMNATHRB
SCHEMBL771749 0.82 PDE3A (0.42) PDE3APDE4DSLC29A1LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180066009-A1 Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools CHEMGENES CORP (US) 2018-03-08 — — US claimed
US-20140350234-A1 Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools CHEMGENES CORPORATION (US) 2014-11-27 — — US claimed
CN-110753756-B Immunomodulatory polynucleotides and uses thereof 华普生物技术(河北)股份有限公司 2023-09-01 — — CN disclosed
CN-114807328-A Method for marking and identifying single-base resolution DNA 浙江大学 2022-07-29 — — CN disclosed
CN-109661232-A NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF 纽约哥伦比亚大学董事会 2019-04-19 — — CN disclosed
CN-106456801-A Inhibitory oligonucleotides for treating tumors SBI生物技术有限公司 2017-02-22 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140350234-A1 Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools UNG, OGG1, ADAR PDE3A 3812/4885PDE4D 1673/4885SLC29A1 109/4885
US-20180066009-A1 Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools UNG, OGG1, ADAR PDE3A 3812/4885PDE4D 1673/4885SLC29A1 109/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.