Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16574049 | 0.71 | TRPV1 (0.50) | MAPTSMN1; SMN2HPGDTSHRNPC1 | |
| SCHEMBL8661973 | 0.70 | KDM4E (0.48) | KDM4ESMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL1120687 | 0.68 | MAPT (0.48) | MAPTSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL28372442 | 0.68 | MAPT (0.45) | MAPTKDM4EALDH1A1PTGESALOX5 | |
| SCHEMBL30541242 | 0.68 | MAPT (0.45) | MAPTKDM4EALDH1A1PTGESALOX5 | |
| SCHEMBL16574051 | 0.68 | PARP1 (0.57) | CNR1 | |
| SCHEMBL9483919 | 0.68 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3168456 | 0.67 | MAPT (0.49) | MAPTSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL5081271 | 0.66 | HTR3E (0.50) | MAPTSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL16574201 | 0.66 | HPGD (0.55) | MAPTTDP1SMN1; SMN2HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876355-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997019932-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | disclosed |