Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835655 | 0.73 | CA12 (0.53) | KDM4ESMN1; SMN2GAALMNAMEN1 | |
| SCHEMBL656591 | 0.72 | CNR2 (0.52) | KDM4ESMN1; SMN2GAATSHR | |
| SCHEMBL20169531 | 0.71 | SMN1; SMN2 (0.59) | KDM4ESMN1; SMN2POLBGAALMNA | |
| SCHEMBL27861387 | 0.71 | GAA (0.63) | SMN1; SMN2POLBGAALMNAMEN1 | |
| SCHEMBL6382412 | 0.71 | SMN1; SMN2 (0.59) | KDM4ESMN1; SMN2POLBGAALMNA | |
| SCHEMBL6096096 | 0.71 | GAA (0.56) | KDM4EPOLBGAALMNAMEN1 | |
| SCHEMBL8687124 | 0.71 | KDM4E (0.53) | KDM4EDUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL8915368 | 0.71 | CA2 (0.48) | KDM4ESMN1; SMN2POLBGAAKMT2A | |
| SCHEMBL2635519 | 0.70 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2POLBGAALMNA | |
| SCHEMBL8661971 | 0.70 | MAPT (0.37) | KDM4ESMN1; SMN2MAPK1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876355-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997019932-A1 | 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | disclosed |
| US-5554607-A | INCREASING HDL CHOLESTEROL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-10 | — | — | US | disclosed |