Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | MITF | O75030 | 1/20 | 0.66 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13203515 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| Bromide SCHEMBL27941533 | 0.89 | KDM4E (0.79) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| Bromide SCHEMBL698678 | 0.89 | KDM4E (0.79) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL765905 | 0.87 | KDM4E (0.76) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| Ammonia Solution, Strong SCHEMBL28760030 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL28520864 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| Bromide SCHEMBL27941532 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL2527501 | 0.85 | KMT2A (0.73) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL8825043 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| Bromide SCHEMBL2691176 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1LMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0681225-B1 | Electrostatic toner comprising phenacyl compounds | BASF AG (DE) | 1998-11-18 | — | — | EP | disclosed |
| US-5541032-A | CHARGE STABILIZERS WHICH ARE INSENSITIVE TO MOISTURE, HEAT RESISTANT AND PRODUCE CRISP, UNIFORM VISIBLE IMAGES OF HIGH COLOR INTENSITY | BASF AKTIENGESELLSCHAFT (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0681225-A1 | Electrostatic toner comprising phenacyl compounds | BASF AKTIENGESELLSCHAFT (DE) | 1995-11-08 | — | — | EP | disclosed |