Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.42 |
| ▸ | FEN1 | P39748 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657561 | 0.88 | PTGS1 (0.43) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8658158 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1ALOX5APFEN1CA1 | |
| SCHEMBL8659726 | 0.88 | ALOX5AP (0.46) | PTGS2PTGS1ALOX5APFEN1CA1 | |
| SCHEMBL8660106 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8661447 | 0.85 | PTGS2 (0.48) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8656122 | 0.85 | F10 (0.41) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8657428 | 0.85 | PTGES2 (0.53) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8661401 | 0.84 | ALOX5AP (0.49) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8661455 | 0.84 | ALOX5AP (0.46) | PTGS2PTGS1ALOX5APFEN1F10 | |
| SCHEMBL8661367 | 0.84 | PTGS2 (0.45) | PTGS2PTGS1ALOX5APFEN1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |