Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | NAT1 | P18440 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.40 |
| ▸ | FEN1 | P39748 | 4/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657561 | 0.90 | PTGS1 (0.43) | F10PTGES2PTGS2PTGS1ALOX5AP | |
| SCHEMBL8659722 | 0.86 | CA2 (0.45) | F10PTGES2PTGS2MAOBPTGS1 | |
| SCHEMBL8660106 | 0.85 | PTGS2 (0.58) | F10PTGES2PTGS2PTGS1ALOX5AP | |
| SCHEMBL8662873 | 0.85 | PTGS2 (0.50) | F10PTGES2PTGS2RAB9APTGS1 | |
| SCHEMBL8659726 | 0.84 | ALOX5AP (0.46) | PTGES2PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8657428 | 0.84 | PTGES2 (0.53) | F10PTGES2PTGS2MAOBPTGS1 | |
| SCHEMBL8662849 | 0.84 | NPC1 (0.40) | F10RAB9AALOX5APFEN1CA1 | |
| SCHEMBL8661401 | 0.83 | ALOX5AP (0.49) | F10PTGS2MAOBPTGS1ALOX5AP | |
| SCHEMBL8661367 | 0.83 | PTGS2 (0.45) | F10PTGES2PTGS2PTGS1ALOX5AP | |
| SCHEMBL8661455 | 0.83 | ALOX5AP (0.46) | F10PTGES2PTGS2PTGS1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |