SCHEMBL8663405

SCHEMBL8663405

NP(O)O.OCC1CCCN1O

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
DPP4 P27487 1/20 0.31
DPP8 Q6V1X1 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL158812 0.89
SCHEMBL1132942 0.89
Ammonia Solution, Strong SCHEMBL1327720 0.87
SCHEMBL16765733 0.82
Succinic Acid SCHEMBL29509251 0.76 POLB (0.50) POLBL3MBTL1MEN1KMT2ADPP4
Biphenyl SCHEMBL7894663 0.73 MEN1 (0.48) POLBL3MBTL1MEN1KMT2A
(Z)-1,2-Diphenylethene SCHEMBL20495486 0.70 MEN1 (0.44) MEN1KMT2A
SCHEMBL571333 0.69
SCHEMBL6332843 0.69
SCHEMBL7614934 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250270562-A1 BIS-RNAI COMPOUNDS FOR CNS DELIVERY BANK OF AMERICA, N.A. 2025-08-28 US disclosed
WO-2024196898-A1 CHEMICALLY MODIFIED NONCODING NUCLEOTIDES CAMFORD LABS INC. (US) 2024-09-26 WO disclosed
WO-2024196893-A1 CHEMICALLY MODIFIED NUCLEOTIDES CAMFORD LABS INC. (US) 2024-09-26 WO disclosed
EP-4367237-A2 BIS-RNAI COMPOUNDS FOR CNS DELIVERY Alnylam Pharmaceuticals, Inc. (US) 2024-05-15 EP disclosed
US-20230257745-A1 Circular siRNAs BANK OF AMERICA, N.A. 2023-08-17 US disclosed
WO-2023283403-A2 BIS-RNAI COMPOUNDS FOR CNS DELIVERY ALNYLAM PHARMACEUTICALS, INC. (US) 2023-01-12 WO disclosed
WO-2022011214-A1 CIRCULAR SIRNAS ALNYLAM PHARMACEUTICALS, INC. (US) 2022-01-13 WO disclosed
US-5714606-A OLIGONUCLEOTIDE HAVING RECEPTOR BINDING SITES; ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS, MEDICAL DIAGNOSIS ISIS PHARMACEUTICALS, INC. (US) 1998-02-03 US disclosed
EP-0739335-A4 PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS INC (US) 1997-04-02 EP disclosed
US-5574142-A DRUG DELIVERY TO TARGET CELLS, ANTISENSE OLIGODEOXYNUCLEOTIDES MICROPROBE CORPORATION (US) 1996-11-12 US disclosed
EP-0739335-A1 PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS, INC. (US) 1996-10-30 EP disclosed
WO-1995018792-A1 PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS, INC. (US) 1995-07-13 WO disclosed
WO-1994013325-A9 PEPTIDE LINKERS FOR IMPROVED OLIGONUCLEOTIDE DELIVERY 1994-08-18 WO disclosed
WO-1994013325-A2 PEPTIDE LINKERS FOR IMPROVED OLIGONUCLEOTIDE DELIVERY MICROPROBE CORPORATION (US) 1994-06-23 WO disclosed