Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8662730 | 0.80 | NPC1 (0.42) | NPC1MAPK1KAT6AMEN1KMT2A | |
| SCHEMBL10547713 | 0.75 | MAPK1 (0.49) | NPC1MAPK1KAT6AMEN1KMT2A | |
| SCHEMBL29484301 | 0.75 | MAPK1 (0.49) | NPC1MAPK1KAT6AMEN1KMT2A | |
| SCHEMBL8759101 | 0.75 | MAPK1 (0.49) | NPC1MAPK1KAT6AMEN1KMT2A | |
| SCHEMBL15266274 | 0.75 | MAPK1 (0.49) | NPC1MAPK1KAT6AMEN1KMT2A | |
| SCHEMBL621024 | 0.75 | MAPK1 (0.49) | NPC1MAPK1KAT6AMEN1KMT2A | |
| SCHEMBL4341886 | 0.70 | MAPK1 (0.67) | NPC1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL30183430 | 0.69 | MAPK1 (0.49) | NPC1MAPK1KAT6AMEN1KMT2A | |
| SCHEMBL6465448 | 0.69 | HCRTR1 (0.52) | NPC1MAPK1 | |
| SCHEMBL31297066 | 0.68 | MAPT (0.53) | NPC1MAPK1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0830133-A1 | THERAPEUTIC COMPOSITION FOR ARTHRITIS | Takeda Chemical Industries, Ltd. (JP) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996033717-A1 | THERAPEUTIC COMPOSITION FOR ARTHRITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | disclosed |