Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | MTR | Q99707 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 5/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666699 | 0.96 | NPY1R (0.33) | NPY1RNPY5RRORCPOLBAOC3 | |
| SCHEMBL8487926 | 0.96 | NPY1R (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8664324 | 0.94 | NPY1R (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8503703 | 0.94 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8479608 | 0.92 | NPY1R (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8503792 | 0.90 | POLB (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8485778 | 0.90 | NPY1R (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8502233 | 0.88 | GAA (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8485593 | 0.81 | NPY1R (0.40) | NPY1RNPY5RAOC3MTRKDM5A | |
| SCHEMBL8668074 | 0.79 | DRD2 (0.37) | POLBGAANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |