Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 4/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | QPCT | Q16769 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664777 | 0.84 | MTNR1A (0.41) | BRS3MTNR1AMTNR1BBRD4QPCT | |
| SCHEMBL8668858 | 0.83 | QPCT (0.58) | MTNR1AMTNR1BBRD4QPCTALDH1A1 | |
| SCHEMBL9097692 | 0.76 | PDE5A (0.52) | MTNR1AMTNR1BQPCTALDH1A1HPGD | |
| SCHEMBL4697180 | 0.74 | CYP11B1 (0.60) | MTNR1AMTNR1BBRD4QPCTALDH1A1 | |
| SCHEMBL10603795 | 0.72 | MTNR1A (0.59) | MTNR1AMTNR1BBRD4QPCTALDH1A1 | |
| SCHEMBL6580573 | 0.71 | BRS3 (0.42) | BRS3SLC22A12PDE5A | |
| SCHEMBL8522968 | 0.71 | BRS3 (0.44) | BRS3ALDH1A1HTTSLC22A12 | |
| SCHEMBL1608654 | 0.71 | HDAC6 (0.49) | MTNR1AMTNR1B | |
| SCHEMBL27441640 | 0.71 | QPCT (0.55) | MTNR1AMTNR1BBRD4QPCTALDH1A1 | |
| SCHEMBL19611398 | 0.71 | MTNR1A (0.62) | MTNR1AMTNR1BBRD4QPCTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5801180-A | ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | EISAI CO., LTD. (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5693652-A | Benzimidazoles for ischemic heart conditions | EISAI CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5576322-A | Anti-ischemic 2,4-diaminoquinazolines | EISAI CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0607439-A1 | NITROGENOUS HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |