Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.53 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.41 |
| ▸ | FEN1 | P39748 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657892 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1PTGES2CA12CA1 | |
| SCHEMBL8663486 | 0.88 | PTGS2 (0.68) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8663404 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1PTGES2CA12CA1 | |
| SCHEMBL8662806 | 0.86 | PTGES2 (0.64) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8658337 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1PTGES2ALOX5APFEN1 | |
| SCHEMBL8660231 | 0.85 | CA2 (0.41) | PTGS2PTGS1PTGES2CA12CA1 | |
| SCHEMBL8661658 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1PTGES2CA12CA2 | |
| SCHEMBL6725895 | 0.84 | PTGS2 (0.74) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL8661199 | 0.82 | PTGS2 (0.57) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL8661256 | 0.82 | PTGES2 (0.46) | PTGS2PTGS1PTGES2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |